Podcast: inControl
Erschienen: 14.04.2023
Dauer: 01:20:40
In this episode, our guest is Mustafa Khammash. Mustafa is the director of the Control Theory and Systems Biology Lab at ETH Zürich and guides us in this episode as we explore Cybergenetics - the cutting-edge intersection of control theory and synthetic biology. From biomolecular control to antithetic motifs, we discuss real-world applications and ethical dilemmas. Don't miss it!Outline00:00 - Intro00:50 - Cybergenetics02:22 - Genetics 10105:07- Where control meets biology06:49 - Mustafa's early steps in biology: why do dairy cows get milk fever?12:05 - Systems and synthetic biology14:34 - History of synthetic biology17:16 - On biological computing23:23 - On biomolecular control29:27 - The birth of the Antithetic motif for molecular feedback control39:25 - Enabling technologies48:28 - How the antithetic motif works57:20 - Model organisms 01:00:45 - Applications of Cybergenetics 01:06:45 - Ethical dilemmas in Cybergenetics01:10:57 - On the internal model principle01:16:01 - Advice to future students01:19:51 - OutroLinks - Mustafa’s website: https://bsse.ethz.ch/ctsb- Paper on calcium regulation: https://tinyurl.com/4p9xu8j2- History of synthetic biology: https://tinyurl.com/2p8ej8fw- Motifs: https://tinyurl.com/3vcnjvj3- Paper - In silico feedback for in vivo regulation of a gene expression circuit: https://tinyurl.com/yw98d8k8- Paper - A universal biomolecular integral feedback controller for robust perfect adaptation: https://tinyurl.com/bddux4x3- Optogenetics: https://tinyurl.com/r6yw9s37- About the fluorescent protein: https://tinyurl.com/bdzm37fs- Electroporation: https://tinyurl.com/3hhjxanp- Paper - Cybergenetics: Theory and Applications of Genetic Control Systems: https://tinyurl.com/222f8924- Paper - Universal structural requirements for maximal robust perfect adaptation in biomolecular networks: https://tinyurl.com/3a2bm35fPodcast infoPodcast website: https://www.incontrolpodcast.com/Apple Podcasts: https://tinyurl.com/5n84j85jSpotify: https://tinyurl.com/4rwztj3cRSS: https://tinyurl.com/yc2fcv4yYoutube: https://tinyurl.com/bdbvhsj6Facebook: https://tinyurl.com/3z24yr43Twitter: https://twitter.com/IncontrolPInstagram: https://tinyurl.com/35cu4kr4Acknowledgments and sponsorsThis episode was supported by the National Centre of Competence in Research on «Dependable, ubiquitous automation» and the IFAC Activity fund. The podcast benefits from the help of an incredibly talented and passionate team. Special thanks to B. Seward, E. Cahard, F. Banis, F. Dörfler, J. Lygeros, as well as the ETH and mirrorlake studios. Music was composed by A New Element. Support the show
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Podcast-Website: Episode "ep11 - Mustafa Khammash: Cybergenetics"
